Comment by Slow_Hand

In short: Not really.

As another commenter below has said, "mathematics might be a useful way to understand music", but it's not how compelling music is made.

Mathematics are fundamental to scales and the harmonic series, and knowing about them will help you refine certain choices, but it's not going to help you write a dramatic melody or an emotionally resonant chord progression, or play an energizing rhythm, even if there are mathematical explanations sometimes.

Good music comes from being a good listener, having a strong sense of what's possible, where it could go, and then delivering something surprising. Telling a story with your melody and supporting the arc of that gesture with harmony that accentuates or contrasts it.

Again, there's a mathematical explanation for harmony and dissonance, but players aren't thinking that granular. They're operating at a higher level of abstraction one, two, or three levels above that: They're thinking about telling a story, evoking an emotion, and exciting an audience in the moment.