Comment by XorNot
9 hours ago
That's because you grew up in a society still deeply coded to puritan moral viewpoints.
People for so upset that GLP-1 has no long term side effects.
There's still the crowd completely sure everyone will get HyperCancer in 10 years or something (they won't).
I'm glad we have GLP-1, and I don't think there are really major side effects. But they are ineffective outside clinical trial setting for treating obesity.
It seems to be like treating alcoholism with disulfiram: it's a miracle in clinical trials but in the real world the patients just lower the doses or discontinue treatment after 1-2 years and go back to their old habits.
> they are ineffective outside clinical trial setting for treating obesity
This is totally false. I know a number of people who took GLP-1 to treat their obesity and then stopped and have stayed not obese.
If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes from random strangers on the Internet.
2 replies →
It is not ineffective outside of clinical trials. All the evidence says that people gain some weight back after they discontinue treatment - which is not a lack of efficacy. But they also usually gain back less then they lost.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12361690/
It's kind of two separate topics: 1. Whether patients can adhere to GLP1. 2. Whether discontinuation leads to weight regain.