Comment by rzmmm
2 hours ago
I'm glad we have GLP-1, and I don't think there are really major side effects. But they are ineffective outside clinical trial setting for treating obesity.
It seems to be like treating alcoholism with disulfiram: it's a miracle in clinical trials but in the real world the patients just lower the doses or discontinue treatment after 1-2 years and go back to their old habits.
> they are ineffective outside clinical trial setting for treating obesity
This is totally false. I know a number of people who took GLP-1 to treat their obesity and then stopped and have stayed not obese.
If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes from random strangers on the Internet.
Do you have a link to those data showing GLP-1 agonists are ineffective?
1 reply →
It is not ineffective outside of clinical trials. All the evidence says that people gain some weight back after they discontinue treatment - which is not a lack of efficacy. But they also usually gain back less then they lost.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12361690/
It's kind of two separate topics: 1. Whether patients can adhere to GLP1. 2. Whether discontinuation leads to weight regain.