1. Why you/penguins should care about this: PFAS suppress immune function and reduce reproductive success in birds [1]. They transfer from mothers to eggs and disrupt thyroid hormones and immune organ development in avian embryos [2]. In humans, IARC classified PFOA as a Group 1 carcinogen in 2023, which means there is the highest classification (i.e. International Agency for Research on Cancer is convinced PFAS causes cancer). A 2x increase in serum PFAS is associated with a 49% drop in vaccine antibody levels in children [3]. These are the same compounds showing up in >90% of penguin samples in remote Patagonia. They don't break down. They bioaccumulate up the food chain. And the "safer replacements" like GenX are clearly reaching the ends of the earth too. This is bad for penguins and for people.
2. This is a problem I'm taking seriously. My startup, NeutraOat (neutraoat.com) is developing a modified oat fiber that selectively binds PFAS and plasticizers in the GI tract without stripping nutrients like charcoal does. It will also remove PFAS from the blood. Early-stage, binding data is promising. Clinical trial happening in ~6-9 months. Website has our early data and a pre-order signup form.
That’s a great idea. Have you compared the effects of your product with non-modified soluble fibers? Afaik, soluble fibers not only from oats but also from vegetables and beans already have solid effects on toxin-binding in their natural state.
My hypothesis is that PFAS and microplastics are responsible for the drop in female fertility, drop in male fertility, drop in testosterone levels, increase in obesity, etc. These chemicals are pervasive in the environment, causing disruptions to the endocrine system that regulates our body. This is why higher elevation areas seem to lag the trends, as they are not getting as much down stream accumulation in the environment. My sister hypothesis GLP-1s are a chemical that is undoing some of that disruption. If what you are doing works, it'll imo be a modern day Norman Borlaug.
I've signed up and look forward to following your success.
Your mission is near and dear to my heart- I grew up on an US Air Force base that is a PFAS superfund site and didn't find out about it until much later in life. Recently I've jumped into research linking PFAS contamination in dog food to canine Addison's disease.
We've been pretty cavalier with PFAS and it's horrifying.
Looking at the studies on the site I’m only seeing comparisons vs placebo and activated charcoal - why not compare to non modified regular beta glucan that is in most oats?
Interesting, best of luck with this, microplastics really are the modern lead.
You said it removes them from the blood: does the body dump microplastics in the gut for your product to remove them from the blood or how does it work (if you can answer due to proprietary reasons)?
Are saunas and blood donations not also effective for this?
PFAS (and, to a lesser extent, plasticizers) circulate from the blood to the gut ~5 times per day through enterohepatic circulation (https://en.wikipedia.org/wiki/Enterohepatic_circulation). This is why cholestyramine was shown to be effective at reducing serum PFAS by up to 60% in a Swedish trial.
Blood donations are also somewhat effective, saunas less so. Also, to be clear, PFAS are very different from microplastics. PFAS are the Teflon chemical.
It's a common misconception, but microplastics and forever-chemicals (PFAS) are not the same thing. They're two similar, but distinct pollutants.
> Are saunas and blood donations not also effective for this?
Yes, plasma & blood donations are good at reducing PFAS blood concentration. Some(?) firefighting foam contains PFAS, so they tend to have high blood concentrations. Donations have shown to significantly reduce that: https://pmc.ncbi.nlm.nih.gov/articles/PMC8994130/
In PFAS's defense, we really needed to poison the whole planet. Otherwise people would have occasionally needed to get wet in the rain, or perhaps scrub their pots and pans. Really, these extremely minor conveniences are worth the devastating cost to ours and future generations.
Saunas helping with any kind of detox is complete hocum.
Blood donations clearly do.
Microplastics and PFAS aren't synonyms however.
What isn't established is a dose dependant harm from PFAS. Some things are harmful in minute quantities to the point it doesn't matter if you have a lot or a little.
Lead has a clear dose response but a relatively low threshold for noticeable harm. It's not clear what PFAS curve will look like.
I won't restart the linear no threshold flame wars about radiation harm but let's just say it's not always intuitive.
One of the issues I see with PFAS testing is that the legal limit is right at the lower limit of detectability for most test equipment. Signals at that level are difficult to read reliably and the accuracy of detection at that level is worse than at higher levels.
It's almost like legislators saw that the machines could ostensibly detect 4 parts-per-trillion and decided that should be the limit without continuing to read the machine manual to describe the reduction in accuracy at that threshold level.
The levels in this test were close to this threshold and there was one outlier sample that severely changed the average results. The testing methodology also involved several laboratory steps where contamination could have occurred.
That's speceist. The whole idea with good science is that you don't need to trust the person. You can evaluate the penguins' study's results and reasoning on its own merits.
That's an abstract ideal. In practice, it is not feasible for most people to verify a study. It is difficult enough for colleagues in the field. Hence why we have to use proxies like trustworthiness of a source.
Is this going to be like the micro-plastics-are-actually-contamination-from-lab-gloves news all over again?
I'm all for removing PFAS and similar chemicals from the many places and uses they aren't needed, but if people don't care about PFAS in their tap water, they certainly aren't going to care about penguin PFAS.
Most people don't care. PFAS is only voluntarily being phased out in food packaging, rather than being banned. People cook with teflon-coated pans for the tiny convenience over a nitrided, ceramic, or seasoned cast iron pan. Outdoors enthusiasts want PFAS rain jackets and PFAS ski waxes, rather than the alternatives.
I definitely agree they need to look at history, consider what they're being exposed to, and understand how simple and easy some of the substitutions/mitigations could be. There's 0 reason why manufacturers are getting 5+ years to phase out a forever chemical in something like ski wax or dental floss.
Future archaeologists are going to chronicle humankind's stupidity by the lead layer, the atom bomb testing fallout layer, the PFAS layer, etc. All of these were made possible by a misplaced sense of scale. Yes we can poison the whole planet. That little blue dot.
Yes, it could be (I posted the article about the gloves), but PFAS are different from microplastics, and not all the studies are contaminated by gloves.
The interesting part here is using the animals as “scientists” to collect samples in their habitats for years (2022-2024) instead of sending humans to collect samples. This is far more reliable in my opinion
The animal angle is fun and interesting, and my quip about the gloves is mostly a joke. My frustration comes from the fact that we don't (or shouldn't) need to know that PFAS is in Patagonia to care about it.
45% of US households contain PFAS, apparently, but no mitigation or even manufacturing bans are required for years.
In the US, one side cries about regular flouride in the water, but is meh to PFAS. Meanwhile, the other side is supposedly pro-environment, but can't even get the fortitude to ban PFAS ski wax.
you missed the full jab -- "most people" did not care about lead pipes for drinking water. It does not take much effort to blankly state that the public "does not care" and proceed to spend less than one minute of thinking capacity to self-confirm and move on. IMHO That is what you see in some of the comments here -- "ignorance" in true form, on display here in a erudite and modern forum. Functional definition of "ignorance" for this topic? I do not know that and I do not care, end of discussion.
Two notes for cynical HN crowd:
1. Why you/penguins should care about this: PFAS suppress immune function and reduce reproductive success in birds [1]. They transfer from mothers to eggs and disrupt thyroid hormones and immune organ development in avian embryos [2]. In humans, IARC classified PFOA as a Group 1 carcinogen in 2023, which means there is the highest classification (i.e. International Agency for Research on Cancer is convinced PFAS causes cancer). A 2x increase in serum PFAS is associated with a 49% drop in vaccine antibody levels in children [3]. These are the same compounds showing up in >90% of penguin samples in remote Patagonia. They don't break down. They bioaccumulate up the food chain. And the "safer replacements" like GenX are clearly reaching the ends of the earth too. This is bad for penguins and for people.
2. This is a problem I'm taking seriously. My startup, NeutraOat (neutraoat.com) is developing a modified oat fiber that selectively binds PFAS and plasticizers in the GI tract without stripping nutrients like charcoal does. It will also remove PFAS from the blood. Early-stage, binding data is promising. Clinical trial happening in ~6-9 months. Website has our early data and a pre-order signup form.
[1] Vendl et al., "Profiling research on PFAS in wildlife," Ecol Solut Evid, 2024. https://besjournals.onlinelibrary.wiley.com/doi/full/10.1002... [2] Halldin et al., "Developmental exposure to a mixture of PFAAs affects the thyroid hormone system and the bursa of Fabricius in the chicken," Sci Rep, 2019. https://www.nature.com/articles/s41598-019-56200-9 [3] Grandjean et al., JAMA 2012;307(4):391–397. https://pubmed.ncbi.nlm.nih.gov/22274686/
That’s a great idea. Have you compared the effects of your product with non-modified soluble fibers? Afaik, soluble fibers not only from oats but also from vegetables and beans already have solid effects on toxin-binding in their natural state.
Wow a non-AI startup doing good for the world (no gambling) in 2026? Ycombinator, someone get OP some money!
Seriously though, amazing idea I love this.
If they’re heading towards clinical trials in 6-9 months, tech investors are the last group of people you want involved.
How are GLPs bad for the world?
2 replies →
>no GLP's
GLPs are similar to gambling?
1 reply →
My hypothesis is that PFAS and microplastics are responsible for the drop in female fertility, drop in male fertility, drop in testosterone levels, increase in obesity, etc. These chemicals are pervasive in the environment, causing disruptions to the endocrine system that regulates our body. This is why higher elevation areas seem to lag the trends, as they are not getting as much down stream accumulation in the environment. My sister hypothesis GLP-1s are a chemical that is undoing some of that disruption. If what you are doing works, it'll imo be a modern day Norman Borlaug.
Excellent!
I've signed up and look forward to following your success.
Your mission is near and dear to my heart- I grew up on an US Air Force base that is a PFAS superfund site and didn't find out about it until much later in life. Recently I've jumped into research linking PFAS contamination in dog food to canine Addison's disease.
We've been pretty cavalier with PFAS and it's horrifying.
Looking at the studies on the site I’m only seeing comparisons vs placebo and activated charcoal - why not compare to non modified regular beta glucan that is in most oats?
Interesting, best of luck with this, microplastics really are the modern lead.
You said it removes them from the blood: does the body dump microplastics in the gut for your product to remove them from the blood or how does it work (if you can answer due to proprietary reasons)?
Are saunas and blood donations not also effective for this?
PFAS (and, to a lesser extent, plasticizers) circulate from the blood to the gut ~5 times per day through enterohepatic circulation (https://en.wikipedia.org/wiki/Enterohepatic_circulation). This is why cholestyramine was shown to be effective at reducing serum PFAS by up to 60% in a Swedish trial.
Blood donations are also somewhat effective, saunas less so. Also, to be clear, PFAS are very different from microplastics. PFAS are the Teflon chemical.
3 replies →
It's a common misconception, but microplastics and forever-chemicals (PFAS) are not the same thing. They're two similar, but distinct pollutants.
> Are saunas and blood donations not also effective for this?
Yes, plasma & blood donations are good at reducing PFAS blood concentration. Some(?) firefighting foam contains PFAS, so they tend to have high blood concentrations. Donations have shown to significantly reduce that: https://pmc.ncbi.nlm.nih.gov/articles/PMC8994130/
6 replies →
In PFAS's defense, we really needed to poison the whole planet. Otherwise people would have occasionally needed to get wet in the rain, or perhaps scrub their pots and pans. Really, these extremely minor conveniences are worth the devastating cost to ours and future generations.
6 replies →
Saunas helping with any kind of detox is complete hocum.
Blood donations clearly do.
Microplastics and PFAS aren't synonyms however.
What isn't established is a dose dependant harm from PFAS. Some things are harmful in minute quantities to the point it doesn't matter if you have a lot or a little.
Lead has a clear dose response but a relatively low threshold for noticeable harm. It's not clear what PFAS curve will look like.
I won't restart the linear no threshold flame wars about radiation harm but let's just say it's not always intuitive.
4 replies →
Impressive and I wish you the best! Hoping you get noticed and get funding.
PFAS, aka endocrine disruptors: https://en.wikipedia.org/wiki/Endocrine_disruptor
This is a massive oversimplification and is not anything even approaching settled science.
They fitted some penguins with chemical-sensing silicone passive samplers.
Did they wear gloves when installing the samplers?
One of the issues I see with PFAS testing is that the legal limit is right at the lower limit of detectability for most test equipment. Signals at that level are difficult to read reliably and the accuracy of detection at that level is worse than at higher levels.
It's almost like legislators saw that the machines could ostensibly detect 4 parts-per-trillion and decided that should be the limit without continuing to read the machine manual to describe the reduction in accuracy at that threshold level.
The levels in this test were close to this threshold and there was one outlier sample that severely changed the average results. The testing methodology also involved several laboratory steps where contamination could have occurred.
https://media.sciltp.com/articles/2603003293/2603003293.pdf
I don't tryst penguin toxicologists, I've never heard of any reputable penguin colleges or labs.
That's speceist. The whole idea with good science is that you don't need to trust the person. You can evaluate the penguins' study's results and reasoning on its own merits.
That's an abstract ideal. In practice, it is not feasible for most people to verify a study. It is difficult enough for colleagues in the field. Hence why we have to use proxies like trustworthiness of a source.
It’s a joke
Are they sure it's not from their gloves?
https://www.sciencedaily.com/releases/2026/03/260329222938.h...
Outdoor gear also contains pfas.
Is this going to be like the micro-plastics-are-actually-contamination-from-lab-gloves news all over again?
I'm all for removing PFAS and similar chemicals from the many places and uses they aren't needed, but if people don't care about PFAS in their tap water, they certainly aren't going to care about penguin PFAS.
> if people don't care about PFAS in their tap water
People don't? Sounds to me like they need to look at history a bit more.
To me, this looks very much like some of the other magical materials...
Lead in gasoline, asbestos as building material, tobacco etc
Most people don't care. PFAS is only voluntarily being phased out in food packaging, rather than being banned. People cook with teflon-coated pans for the tiny convenience over a nitrided, ceramic, or seasoned cast iron pan. Outdoors enthusiasts want PFAS rain jackets and PFAS ski waxes, rather than the alternatives.
I definitely agree they need to look at history, consider what they're being exposed to, and understand how simple and easy some of the substitutions/mitigations could be. There's 0 reason why manufacturers are getting 5+ years to phase out a forever chemical in something like ski wax or dental floss.
14 replies →
Future archaeologists are going to chronicle humankind's stupidity by the lead layer, the atom bomb testing fallout layer, the PFAS layer, etc. All of these were made possible by a misplaced sense of scale. Yes we can poison the whole planet. That little blue dot.
2 replies →
Yes, it could be (I posted the article about the gloves), but PFAS are different from microplastics, and not all the studies are contaminated by gloves.
The interesting part here is using the animals as “scientists” to collect samples in their habitats for years (2022-2024) instead of sending humans to collect samples. This is far more reliable in my opinion
The animal angle is fun and interesting, and my quip about the gloves is mostly a joke. My frustration comes from the fact that we don't (or shouldn't) need to know that PFAS is in Patagonia to care about it.
45% of US households contain PFAS, apparently, but no mitigation or even manufacturing bans are required for years.
In the US, one side cries about regular flouride in the water, but is meh to PFAS. Meanwhile, the other side is supposedly pro-environment, but can't even get the fortitude to ban PFAS ski wax.
2 replies →
No, they-are-not-actually-contamination. Some studies might have inaccurate numbers due to contamination. That's all.
Important to correct for, but doesn't invalidate the whole microplastics concern.
Just like how people never cared about lead in their tap water.
you missed the full jab -- "most people" did not care about lead pipes for drinking water. It does not take much effort to blankly state that the public "does not care" and proceed to spend less than one minute of thinking capacity to self-confirm and move on. IMHO That is what you see in some of the comments here -- "ignorance" in true form, on display here in a erudite and modern forum. Functional definition of "ignorance" for this topic? I do not know that and I do not care, end of discussion.
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