Comment by vbezhenar

If you're worried about that, you can just disable WebUSB in the chrome settings. Any website will be denied access to that API from now on. And what's even better: you can selectively enable WebUSB for some websites.

That's what I do and that's what I suggest for any security-conscious user to do. Just explore Chromium settings, there are dozens of various APIs that could be disabled. Do you need Web MIDI? I don't. Disable.

Won't work as a default setting for average user for sure, but if you consider yourself an advanced user, do that.