Any app using memory allocation functions would benefit from a newer heap implementation independently of a technology it's created with, unless it's actively constrained by compatibility burdens. In case of .NET, the memory layout compatibility is not something you usually care about unless the app loads old 3rd party .DLLs through P/Invoke. So for 99.9% of .NET (not Framework) apps, the segment heap should work just fine.
Any app using memory allocation functions would benefit from a newer heap implementation independently of a technology it's created with, unless it's actively constrained by compatibility burdens. In case of .NET, the memory layout compatibility is not something you usually care about unless the app loads old 3rd party .DLLs through P/Invoke. So for 99.9% of .NET (not Framework) apps, the segment heap should work just fine.