Comment by imtringued
6 hours ago
I don't know what you mean by end to end loss optimization in particular, but if you mean something that involves global propagation of errors e.g. backpropagation you are dead wrong.
Predictive coding is more biologically plausible because it uses local information from neighbouring neurons only.
By end to end loss optimization, they mean evolution: Try a thing, and see if it dies or reproduces more. Repeat until moon landing.