Comment by well_ackshually

All of these, and more. Macbook Neos benefit from all the hardware that Apple makes in-house, reusing CPUs that they already make for iPhones but didn't make the cut, have zero upgradeability, benefit from massive economies of scale, contracts are already signed in advance, the delivery and logistics of an existing chain...

Framework has to go talk to Intel and AMD, get parts shipped, assembled onto a motherboard that they have to make themselves and ordered in very low amounts then shipped all to their fulfillment center, then fedexed, have to source components... Even not taking into account the fact that Apple already has all of the hardware made or available in-house, just the supply and logistics chain is an easy 10% of the final price.