Comment by ElProlactin
8 hours ago
...HSV would be extremely low on my list.
I think this is a bit of an unfair conclusion.
First, while you're correct that most people who have HSV have few symptoms (if any), you're discounting the fact that, because so many people are infected, there are millions upon millions who have highly-visible and highly-painful infections. Many of these people struggle with relationships and mental health as a result.
Second, HSV is associated with higher risk of HIV infection for obvious reasons.
Finally, discovering effective treatments for such a difficult virus would probably produce insights that have implications for other difficult-to-target viruses.
So I don't think we should dismiss HSV on the basis that it's so common and doesn't cause life-threatening symptoms. Medicine should pay adequate attention to infections that affect quality of life for large numbers of people.
Billions are spent on treatments for super rare diseases, many of which are terminal, and in the best cases the end result is often that pharmaceutical companies have drugs costing tens or hundreds of thousands of dollars that extend life by months (often with dubious quality of life).
Yeah HSV on its own would be awesome to find a good vaccine for but the insights it would give for vaccinations against the broader human herpes virus family would be massively impactful.
A successful HSV vaccine would also almost certainly lead to a vaccine for epstein-barr, cytomegalovirus, and roseolovirus.
Even ignoring the thousands of connections HSV is suspected to have to other diseases, getting insight towards the other 3 big "uncured" HHVs would be a massive deal.
EBV/mono is a silent but debilitating disease that infects a near majority of the population even in "developed countries" and is all but confirmed as a requirement for developing multiple sclerosis. EBV is also directly connected to a long list of cancers as well.
cytomegalovirus and roseolovirus while less common in the developed world are still far too common and globally are major sources of harm for infants and young children.
Any steps towards effective vaccination against the broader family of HHVs would be monumental.