Comment by gravelc
6 days ago
Tried this to see how it goes in my particular field - computational design of RNAi-based biopesticides. One-shotted a design for targeting the DvSnf7 transcript of western corn rootworm. It took a fairly naive approach (maybe how a 1st year PhD student would go about it), but got the job done. Also noted caveats with its approach (e.g. using mammalian design rules, limited off-target screening). Not bad really. But also not great. When its flaws were pointed out, the AI determined that it could have taken a more informed approach. Then Opus 4.8's safety system flagged the session.
> Then Opus 4.8's safety system flagged the session.
The jokes write themselves these days.
I suggest collecting 10 seminal works on the subject matter including 10 textbooks in the general field, converting them to plain text via OCR or text extraction, then trying the same thing with a superior agentic harness, like omp.sh
/goal set create biopesticide targeting the DvSnf7 transcript of western corn rootworm
<sarcasm>make no mistakes</sarcasm>
> Then Opus 4.8's safety system flagged the session.
If you think you can use this to land real positive impact, you, your institution, or your company should apply for OpenAI and Anthropic's bio programs!