Comment by hallole
2 hours ago
>Stimulants have a habit of being enjoyable at first ... and then the effects wane over the years
The standard approach to addressing this is thru the use of "drug holidays," regular short periods during which one doesn't take their medication with the intention of abating the growth of tolerance. I much prefer going this route since stimulants have proven to be such a solid solution. The other standard approach is, of course, upping dosage, which could be seen as only delaying the problem.
I don't disagree with anything you wrote, though. The internet is indeed a terrible place to get any advice on these topics.
Drug holidays can make a small impact, but tolerance is going to build to many of the effects no matter what you do.
The other problem with drug holidays is that some people start getting into cycles where they don’t take the drug and have lazy days where they justify not doing anything, then they wait for the drug to kick in on the return day to even try doing anything. The housework and personal life things pile up on the off days and then they try to speed around and do it all on the medication days, which is another pattern that isn’t sustainable forever.
Drug tolerance doesn’t build and then abate in a very asymmetric manner where someone could take it for 30 days and then have a couple days off and reverse it all. Some of the biochemical mechanisms of tolerance have persistence measured in months or years.
If you feel you're getting tolerance to amphetamines, the first thing to try is magnesium glycinate/threonate supplements, and then hydration and diet and sleep.