Comment by estearum
9 hours ago
The first paper shows no evidence of any effect from Tylenol...? But yeah seems like lots of support for the ibuprofen protective effect, interestingly.
9 hours ago
The first paper shows no evidence of any effect from Tylenol...? But yeah seems like lots of support for the ibuprofen protective effect, interestingly.
If you do start munching on advil; note there are rumors, by medical researchers, case reports, and more, that if you dig beneath the shiny surface to find, do show a lot of compelling data for GI damage, heart risk and other serious side-effects. And depending on how fair one wants to be with 'evidence' -- almost all wording describing NSAIDs as "protective", uses easy-to-miss but distinct qualifiers such as "potential" and other such vague 'maybe'-equivalents that alone have been used to suppress and dismiss many other...potential medicines. Sometimes, conclusive just means inspired. And sometimes ambiguity means certainty, depending on levels of inspiration involved.
Of course, one might pause for a moment to consider just how potential the alluded benefits really are with ibuprofen, and ask why doctors aren't recommending it for mental health, or as a general health product. But that might point to the peculiar fact that there is substantially more evidence suggesting risk over health benefits, and the benefits really depend on what one wants to see. There is a reason it's not marketed as a health product, but with the way it's framed, it should be, nu? I mean, potential benefits sells a lot of snake oil and lowfat yogurt. Why not advil and acetaminophen?
And by similar logic used to dismiss acetaminophen here as a health risk, eg because there's no link with autism/ADHD it's safe; why not apply the same logic to opiates? We could just say opiates do not directly cause, eg , parkinsons, or AIDS, therefore it's safe for babies. Myself, I never correlated acetaminophen with autism/ADHD, but I know it has more side-effects than listen on the bottle.
Yeah I work in clinical trials so I'm very comfortable with all the caveats the need to be applied to correlative studies like these.
Which also answers your other question of why doctors don't recommend it: we don't actually know that it does this.
As for the rest of the ramble, you (or I) definitely don't know hardly anything that hasn't been established in clinical trials. Certainly can't just vibes-based assess a label and its completeness. It's really, really hard to know things.
The precise wording as far as safety is: "we have no substantive or high-quality evidence that the drug is unsafe."
Because we couldn't possibly modify
"we have no substantive or high-quality evidence that the drug is unsafe." - (damn all the research showing it is)
--to
"we have no substantive or high-quality evidence that the drug is safe." - (damn all the research suggesting it isn't)
Well, that's as good a green light for an ad campaign as one could ask for. "we don't actually know that it does this." ain't never stopped a motivated pharmaceutical rep before. You have my official endorsement for feeding advil and acetaminophen to all. And protection from dementia is just what America needs. !Win / !Win
Maybe restless leg and depression too! And don't tell me fetuses don't get depressed there in that dark womb. We know damn well they get restless.
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