Comment by __MatrixMan__

I'm not who you're responding to, but I have a lot of questions about molecular mimicry: evolution pushes pathogens to be shaped like human cell surfaces because that way the immune system won't attack the pathogens (since, by doing so it would also attack the body). It's thought that many autoimmune disorders have an undiscovered pathogen as their cause, one whose mimicry caused such an attack. Discovery of these pathogens could be done computationally, I think. We can catch MHC binding event in process, find the bound protein, figure out which pathogens have genomes that code for proteins of similar shapes (epitopes), and we'd find--I hypothesize--a list of candidate pathogens for the cause of a delayed onset autoimmune disorder. Preventing these infections ahead of time would be a huge win against diseases like multiple sclerosis because without the initial exposure the immune system wouldn't have cloned so many of the cells that are attacking the host.

Claude was utterly useless in my attempts to write a paper about this. Wouldn't even help me search for sources. I guess you'd be asking the same questions if you wanted to develop a pathogen that could reliably evade the immune system.