Comment by ethbr1
1 day ago
Phase I testing is ~$5M. Phase II $6-20M. Phase III is $10-50M. https://pubmed.ncbi.nlm.nih.gov/26908540/ (up to 2012 numbers, non-inflation-adjusted)
Those costs are strictly for the mandatory testing, not the precursor drug design, etc.
The cost and calendar time required to be sunk before 10% pay off is why you generally only have drug development done by (a) some of the largest corporations in the world or (b) fly-by-night companies hoping to sell their preliminary drugs/results to the former to complete testing.
tl;dr -- Boom's iterations are very similar to a phase III trial! Please prove me wrong!
Just to clarify, I think our numbers are in agreement here. From your numbers, phase I + II + III would be in the range $21-75M, all told. Let's double that to account for inflation (2012 is quite stale), to get $42-150M. In California, I'm going to estimate a "normal" engineer's compensation is $150-400k, and the company actually pays more than this because of benefits, HR, etc -- call it $250-600k. Let's say it's 350k fully loaded on average. Then the $42-150M number represents 120-430 engineer years. I'd totally believe that Boom has 120-400 engineers working full time, so if they make a major revision every year, then each major revision is like a full phase I-III progression!
I think there's some reverse-dunning-kruger going on in this thread, where because we're all engineers we think engineering is comparably easy. My claim is that it's actually pretty similar to medical testing, in terms of generic human effort (to the extent that can even be measured and quantified).
edit: According to wikipedia, Boom had 150 employees in 2021 [1]! I'm very proud of my estimate lol, it seems like it was right on the nose. Somebody give me a prize!
[1] https://en.wikipedia.org/wiki/Boom_Technology