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Comment by rootusrootus

19 hours ago

> we are already seeing concerning GI issues emerging from prolonged usage

Could you elaborate? I have been looking for a scientific discussion on that topic and coming up with not much.

Here are some hits from a search for “studies on GI problems associated with GLP1's.” I have not read them start to finish but it’s a starting point for you to do your own searches off of. I used Kagi, for reference.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10213739/

https://www.mayoclinicproceedings.org/article/S0025-6196(25)...

https://www.ncbi.nlm.nih.gov/books/NBK551568/

https://pmc.ncbi.nlm.nih.gov/articles/PMC9821052/

https://www.nature.com/articles/s41366-025-01859-6

  • Ah, okay, I was thinking you might have run across something more recent. The latest science seems to be going mostly in the opposite direction, saying that with additional data it looks like early concerns about things like pancreatitis (and worse, cancer) were overblown. If there are some newly identified adverse reactions I'm always interested to learn more about them.

    • I don’t know what exactly this is but it rubs me the wrong way. You say you’re curious and can’t find anything, but then you dismiss all the stuff I linked in minutes as if no valid literature exists yet and you already have a formed opinion. It doesn’t seem like you’re particularly curious and it feels like my time is being wasted by a lack of transparency.

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