Comment by handedness

Generally speaking, if your Wi-Fi works on Debian and/or Fedora, it should work on Qubes OS. There are exceptions to that, of course.

On a desktop PC you'll have to make some tradeoffs versus most laptops, namely integrating sys-net and sys-usb, but the installer will handle that for you. You'll want to auto-accept your keyboard and mouse, and try not to shut down sys-net. But you'll learn. Since your concern is isolating software you're running, and not necessarily isolating untrusted USB devices, that's not a big loss.

Give it a shot on a few machines and report back. Even better, try it and submit HCL reports to inform others: https://www.qubes-os.org/hcl/ Intel is generally easier than AMD, but I've run it on pretty modern AMD mobile chipsets with a lot of success.

Again, kernel-latest is your friend, and look online to see if anyone recommends any particular kernel flags.