Comment by frm88

The “nurture” explanation that I’m more inclined to, which is more optimistic, is that our culture changed, that people became risk-averse; science became feminized, bureaucratic, and regulated

... The Boomer kids were weaned off violent childhood literature like Tintin and the Hardy Boys and fed a diet of Dr. Seuss.

https://www.harvardsalient.com/p/interview-with-peter-thiel

One specific change that would accelerate drug development would be getting rid of the need for double-blind studies. If a drug is safe, you would just let people use it and not slow things down massively with a double-blind study.

Same link. Theres another interview with him - I can't remember which - where he proposes to test new Alzheimer drugs directly on patients because (paraphrased) they die anyway.

This does not sound like science.