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Comment by evolarjun

20 hours ago

It is odd (or maybe not) that they decided to publish a marketing whitepaper rather than a more traditional journal submission + preprint. The work does appear to be sufficient for a publication, though there's a good chance a reviewer will rip into them for some of the assertions they make, but given the topic I'm sure the paper will be accepted regardless.

The market for entry-level programmers has already declined, but at least they were somewhat in demand and made reasonable salaries. Now what happens to post-docs who already make almost nothing and often get treated like crap?

Did anyone read the blogpost? They did publish a pre-print:

  > Our work to understand the primary function of ARTs is ongoing. However, we think it is important to share such findings early, both to demonstrate Claude’s capabilities and to give the broader community insight into what we’re working on. We have released a pre-print (here) that discusses this in more detail.

https://www-cdn.anthropic.com/22573675ada52a8ca8a97a1a4b4326...

  • I don't recall that being there when I first read their post a few hours ago... No way to confirm, sadly, as they've posted it to their own domain

  • I just looked at it. I really hope they're not thinking of sending that to an actual bioinformatics, computational biology or molecular biology journal! So embarrassing...

    (I love how Anthropic boast about building a lab, but don't seem to realise that you have to test your hypothesis in the lab! Right now, all their "spectacular" assertions are untested and unproven.)

    I realise that this will only improve from here, but gods Anthropic has no idea about the biological sciences right now.

    • Um. Take a look at the authors. Every single one of them is an expert in this field. They did test this in a lab.

      If you want to complain about things like this, it really helps to be specific. Given the author list, it's unlikely they made any truly spectacular errors (and also possible the system they studied is not interesting).

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  • What's with all this pre-print business. It became very prevalent during covid, where it felt like every week some new pre-print was published that discusses some new aspect of the virus. These papers would then be used in arguments and put forward as proof of whatever claim the arguer was making.

    Every man and his dog can publish a pre-print and in my opinion it's academically worthless.

    • Preprints are just a way to sacrifice rigor for accessibility and velocity. You can throw out "here, this is what I'm working on, here are the quick and dirty findings" really fast and with little friction.

      This does skip the academic "checks and balances" like journal selection and peer review - but it can also help anyone else who's working on the adjacent topics.

      If a field is moving fast, and you think there can be some value in your work for others in the near term? Preprint. If your work is too incomplete or too minor to warrant trying to polish and publish it, but you don't want to table it? Preprint. Too deep in corporate structures to care about academic "street cred", and want your work to be accessible? Preprint. Have an exciting early finding that you want to push out there, and are willing to take the rep risks of being wrong about it? Preprint.

      There's a reason why preprints came to be the lifeblood of ML.

      2 replies →

    • I have a similar to pagerank method I use to evaluate such papers. I look for the references to see how many authors are using their own references (past work), the idea being that people do not jump too far, they make incremental progress.

      For the pre-print I could only find only one author who has a single referenced article.

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    • Journal articles are usually behind a paywall. Preprints are a fully open workaround allowed by most journals.

      > Every man and his dog can publish a pre-print and in my opinion it's academically worthless.

      Sure but if you look at the authors names and see they have 50 other published papers, you can get a rough idea that it's probably equivalently good to their other work.

      Until you've done it yourself, it's hard to grok just how bad the peer review process is. It's like...5% better than nothing.

      Honestly you could argue peer review is worse than nothing, as it also filters out actually quality work that violates some dogma of the field.

    • The review time on top journals is multiple years now (your paper will go through many review loops each of which takes months). It's just totally unworkable for active research, whether you're a student or a corporation.

Medical advances are more important than post docs

  • Absolutely. But without post docs, it won't be long before we are unable to understand what the LLMs are suggesting.

    • many drugs were discovered, evaluated and approved without understanding at all how they worked.

      iirc back in the day chemists synthesized a whole bunch of random compounds, observed their effects (in mice etc., or even the chemists tasting them!) then did clinical trials to measure safety and efficacy.

      high-throughput screening of chemical libraries on in vitro assays is the modern version of this. "rational" drug design, which uses understanding of mechanisms to design chemical structures for a specific purpose, largely failed back in the '80s.

      7 replies →

    • There will always be a %age of humans who will be curious how the universe works including LLMs. Delusional to think those humans are only incentivized by degrees, or money.

      Humans were curious and started the intelligence / learning explosion much much before money and degrees were invented.

      2 replies →

  • This is a bit like saying that shoes are more important than shoe factories. Yes, sure, I can't wear a shoe factory, but we'll all run out of shoes if all the factories are gone.

  • Perhaps if you assume we will continually be offered highly valuable medical advances into the future without humans who understand it.

    That's a big assumption to make, so I hope you at least have some proof to back it up.

  • Medical advances require post doc levels of education and knowledge to advance. Otherwise we are pretty soon unable to determine what is trash and what is useful. It is easier to generate trash data than good data, and most data generated will be trash, so if nobody can sift through the good and bad the next level is going to be ingesting nonsense and getting worse every time.

  • Post docs is the base that AI was born from...

    We still need post docs. What will change is their specializations.

    That's why nobody writes their paper on gravity or polio in 2026.

> The market for entry-level programmers has already declined, but at least they were somewhat in demand and made reasonable salaries. Now what happens to post-docs who already make almost nothing and often get treated like crap?

Waiting for frontier labs to get into Political Science to show that SOTA models can be vastly better politicians...

Why do you think they're going to be treated badly? Right now, I think it's kinda accepted that the people best suited to directing AI for programming tasks are programmers - only we operate at a higher level.

Claude's going to be a similar productivity booster to researchers and postdocs.

I'd be totally lost talking to an AI about biochemistry.

Novel discoveries are now marketing ads.

  • If individuals had power to allocate funding or not to public research projects rather than get a blanket tax, there would be a lot more conventional marketing in the public sector as well.

No, it's not odd; IMO. It's by design.

I see all of this leading to a setup for: We did cure Cancer, everyone else (Healthcare, Gov., Rx) etc... has just not caught up or even worse; "you just don't have access top that model/version".

I have seen several times on HN recently how people don't see the impact of AI/more code etc... and I believe this is because its following the K-shape of the current economy.

At the top where most of us aren't but CAN see via stock market news etc...; they are making more money by adding efficiencies etc...

At the bottom; efficiencies are being applied at a scale that they could not before such that social and Gov. programs are more manageable and optimized at scale.

> Now what happens to post-docs who already make almost nothing and often get treated like crap?

At least in the US, that particular brain drain has already been happening due to Trump's administration. The best of the best are exiting to other countries that will gladly have them, and then there will be far fewer people getting into the field. Science in general has taken a massive hit under the current administration and it going to take decades to fix if it's even possible.

> Now what happens to post-docs who already make almost nothing and often get treated like crap?

This sort of discoveries are what gets postdocs funded lmao.

Every new idea like this creates several years worth of highly specialized work to test out derivative ideas, productizing it, and connecting dots to existing work.

I’m curious, what differentiates this from a preprint given the assumption it’s sufficient for publication? It didn’t read like marketing, they don’t seem to sell anything, and there's a link to a not-anthropic.com hosted paper.

  • > they don’t seem to sell anything

    i'll give you a hint: they're selling something

    • Let's say "anything talking about your product is selling something instead of doing science"

      Then we're faced with "why would a (insert whatever makes this a preprint) mean they're not selling something"? (well, at least OP is faced with that, FWIW I think there's ~infinite snarky replies available, but they're sort of uninteresting, no? :)

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  • "Look at what our product achieved" isn't selling anything? Do you want to take at this bridge I'm selling?

    • Sure! (presuming it's "take a look at" :)

      After I entertain you by doing that, is there a steelman version of my reply you're interested in entertaining me with, by replying? Or, just the strawman?

It's not odd at all. Every single "AI did this cool thing" type post is an Ad. Remember AI outputs slop and never produced anything valuable that wasn't heavily assisted by humans or is a lie.