many drugs were discovered, evaluated and approved without understanding at all how they worked.
iirc back in the day chemists synthesized a whole bunch of random compounds, observed their effects (in mice etc., or even the chemists tasting them!) then did clinical trials to measure safety and efficacy.
high-throughput screening of chemical libraries on in vitro assays is the modern version of this. "rational" drug design, which uses understanding of mechanisms to design chemical structures for a specific purpose, largely failed back in the '80s.
True, but it's also not your job to understand what post-docs are suggesting (hopefully), unlike post-docs who kind of need to understand what LLMs are suggesting.
Not to get back into the AI safety debate from last week, but I really, really want a team of human experts to understand what the AI is suggesting before we administer new medical treatments or synthesize new lifeforms in the lab.
There will always be a %age of humans who will be curious how the universe works including LLMs. Delusional to think those humans are only incentivized by degrees, or money.
Humans were curious and started the intelligence / learning explosion much much before money and degrees were invented.
For most of history we died of easily preventable diseases because we lacked the scientific institutions to learn how to prevent them. The fact that a percentage of the population wanted to know more is why we live so well today, but it didn’t stop many of those people from dying awfully. It wouldn’t take a lot to go back there, or at least to a civilization that would go back there the second the AIs have a major outage.
Sure. But unless they are born into a very wealthy family, or decide to pass up on having a family and other hobbies, they won't be able to satisfy that curiosity beyond a very basic level.
This is a bit like saying that shoes are more important than shoe factories. Yes, sure, I can't wear a shoe factory, but we'll all run out of shoes if all the factories are gone.
Medical advances require post doc levels of education and knowledge to advance. Otherwise we are pretty soon unable to determine what is trash and what is useful. It is easier to generate trash data than good data, and most data generated will be trash, so if nobody can sift through the good and bad the next level is going to be ingesting nonsense and getting worse every time.
Absolutely. But without post docs, it won't be long before we are unable to understand what the LLMs are suggesting.
many drugs were discovered, evaluated and approved without understanding at all how they worked.
iirc back in the day chemists synthesized a whole bunch of random compounds, observed their effects (in mice etc., or even the chemists tasting them!) then did clinical trials to measure safety and efficacy.
high-throughput screening of chemical libraries on in vitro assays is the modern version of this. "rational" drug design, which uses understanding of mechanisms to design chemical structures for a specific purpose, largely failed back in the '80s.
Well I guess who gives a shit about knowledge
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I can't understand what the post-docs are suggesting.
True, but it's also not your job to understand what post-docs are suggesting (hopefully), unlike post-docs who kind of need to understand what LLMs are suggesting.
Not to get back into the AI safety debate from last week, but I really, really want a team of human experts to understand what the AI is suggesting before we administer new medical treatments or synthesize new lifeforms in the lab.
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If you can't, then you aren't in the field, and it doesn't matter if you could or not.
There will always be a %age of humans who will be curious how the universe works including LLMs. Delusional to think those humans are only incentivized by degrees, or money.
Humans were curious and started the intelligence / learning explosion much much before money and degrees were invented.
For most of history we died of easily preventable diseases because we lacked the scientific institutions to learn how to prevent them. The fact that a percentage of the population wanted to know more is why we live so well today, but it didn’t stop many of those people from dying awfully. It wouldn’t take a lot to go back there, or at least to a civilization that would go back there the second the AIs have a major outage.
Sure. But unless they are born into a very wealthy family, or decide to pass up on having a family and other hobbies, they won't be able to satisfy that curiosity beyond a very basic level.
once everyone lives to 200 yo there will be no need for post-docs - afterward we can just upload PI's brain to some AI.
I wonder who's going to pay for that extra 120 years of living we're gonna be doing?
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This is a bit like saying that shoes are more important than shoe factories. Yes, sure, I can't wear a shoe factory, but we'll all run out of shoes if all the factories are gone.
cobblers used to make and mend shoes before shoe factories existed..
Perhaps if you assume we will continually be offered highly valuable medical advances into the future without humans who understand it.
That's a big assumption to make, so I hope you at least have some proof to back it up.
Medical advances require post doc levels of education and knowledge to advance. Otherwise we are pretty soon unable to determine what is trash and what is useful. It is easier to generate trash data than good data, and most data generated will be trash, so if nobody can sift through the good and bad the next level is going to be ingesting nonsense and getting worse every time.
Post docs is the base that AI was born from...
We still need post docs. What will change is their specializations.
That's why nobody writes their paper on gravity or polio in 2026.
Then we end up like that anti-aging guy and end up older and giving ourselves untreatable diseases
But do we get any without them?