Comment by D-Machine

There is no world in which CAR-T is a "cure", especially since this isn't even a scientific term in oncology. We generally say if there is no relapse after 5 years post-treatment, then any cancer is a "new" cancer, so 5 years of remission is the closest thing to a "cure", but this isn't a scientific term.

Also, we barely have more than 3 years data for CAR-T for most cancers. And even still, the survival rates aren't great, in many cases 50% compared to e.g. ~20% for previous chemo-immunotherapies plus marrow transplants. And this ignores how massively immunocompromised (or so permanently brain-damaged you are effectively senile) CAR-T can leave you. You can be severely immunocompromised (literally identical to or worse than AIDS / late-stage HIV) for at least a year in close to half of cases, but maybe even permanently, in perhaps as high as 10% of cases (at least for lymphomas).

I say this as a person that is only alive because of CAR-T treatment 1.5 years ago. CAR-T is amazing, and a far better treatment than previous treatments, but calling it a "cure" is deeply misleading and mostly clueless. Currently, it is simply a much better last-ditch effort than the previous ones.