Comment by mey

To build on the economic/practical issues.

The useful life of cutting edge AI server hardware will require constant rotation of equipment to potentially remain competitive with more accessible solutions.

Heat management ( https://m.youtube.com/watch?v=-w6G7VEwNq0 )

Hardening of equipment for the environment. ECC isn't going to be enough. I would have to defer to experts about the best way to manage it, but it either means custom hardware, weight, or both.

Repairs are impossible. Hopefully a sat can degrade gracefully, but routine repairs on earth become significant outages/decreases in economic value of a sat over time.

Rocket launches have gotten much better, but are not perfect. Insurance is a thing. However, cost of equipment in a failed launch may be eye watering, rivaling a governmental military launch.