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Comment by lovich

5 hours ago

I think a lot of people don't realize the Black Plague is bacterial and we already have a cure for it. Most people getting anxious probably assume its like Covid and a cure would have to be developed.

Another thing is that the Black Plague symptoms are pretty horrible, enough to cause anxiety even if you know there is a cure.

  • I guess that’s true. I’ve literally had worse but I’m in a small minority so maybe discounting the effect of that experience.

I've got bad news for you. It may seem like a good thing that Y. Pestis is bacterial since we have antibiotics but remember that bacteria can become antibiotic resistant. You might say "no problem, that would only happen if there were a lot of cases and people weren't properly using antibiotics" and while this is true it is also possible to deliberately make Y. Pestis antibiotic resistant. "Who in their right mind would do a stupid thing like that?" you may ask, well it turns out the Soviets did and likely stockpiled large amounts of it with plans to deliver it in an aerosolized form over cities. Aerosolized particles are how you contract pneumonic plague which if you can't treat it with antibiotics is nearly 100% lethal in all cases. It can also be passed from human to human via coughing. So, here's hoping that this is just a rare case of wild type Y. Pestis that the lab worker somehow unfortunately inhaled and didn't get treatment for in time.

  • Answered this in another comment but my major fear if a bacterial plague like this became a pandemic would be our manufacturing output keeping pace with demand, not like during covid when it was not clear if it was even possible to create a cure.

Do you have a theory for why that researcher died?

  • I think it's pretty apparent from the news articles about it. She died of pneumonic plague, which is a fast-moving form of Yersinia Pestis infection that is roughly 100% fatal if first treatment occurs > 24 hours after symptoms start.

    Why pneumonic plague? Pneumonic plague is the form of infection that occurs when plague bacteria are inhaled in aerosolized form into the lungs, or when septicemic plague (plague in the bloodstreams) reaches the lungs. Like, for example, when a test tube breaks. Her method of infection was a pretty textbook vector for pneumonic plague. Other cases have been caused when tissue samples of infected rodents have been splayed open, for example, or when blood from an infected person splatters the respiratory tract. Plague bacteria spreads pretty poorly otherwise, which is why the main vector for bubonic plague is flea bites.

  • If it's the pneumonia style (i.e. the infection is in the lungs, not the lymph nodes) you have to start antibiotics very quickly or it's basically 100% fatal. So it's treatable, but only to a point. The good news is basic masks and quarantine are extremely effective, so the risk of outright spread beyond the initial patients and very early health care workers is very small.

there is not information that's exactly the same bacteria and that drugs work. It might be novel one or modified in the lab. Even for flu we don't have general vaccine that works.

  • Yes, the fact that is the plague is less worrying than it is plague from a bio research lab that escaped. The only unfounded, non verified news i have read is that it can from collecting of samples, not post experimenting. But your guess is as good as mine at this point

  • And there might be a teapot on the other side of the sun.

    It’s bacteria, antibiotics work more generally than vaccines for viruses do.

    There are of course, antibiotic resistant bacteria but we still have some exotic antibiotics in our arsenal.

    If anything for a widespread bacterial plague I’d be more concerned about our ability to produce enough antibiotics rather than _if_ we could develop a cure