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Comment by tombert

4 days ago

I'm not on GLP-1s, but I am on metformin [1] which my wife says has similar food aversion properties to the GLPs, and for me I've noticed virtually anything with peanut butter I can still eat a nearly infinite quantity of. One of the worst things that has ever happened to me was finding out that peanut butter fudge is ridiculously easy to make.

[1] Off label for weight loss. My insurance wouldn't cover GLP-1s, and metformin is out of patent and super cheap, and I read that at least some people have had good success using it for weight loss. I am fortunately one of those happy few.

When we say food 'aversion', we're implying that a drug like metformin makes you not want that thing, yes?

I've found when I take metformin, and then eat food later, I enjoy the food so much more as a craving/satiation thing. Especially steaks. But I'm not quite sure why that is. I can't say that what peers have told me about metformin is to help with weight loss, but supposedly the benefits/effects on the body are generally positive.

  • In my case metformin makes it so I just have no appetite, and certain foods are outright kind of revolting to me now. I can't do fried chicken while I'm on it.

    • I'm sorry that happens, though now I'll be curious to be on the lookout for this when I take it.

      Out of curiosity, does that effect subside fairly quickly e.g. once the drug half life and has exited your system, do you crave/can you eat chicken fairly comfortably?

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One extreme option if you wanna kick the ‘butter — I ate a small amount of peanut butter immediately before a severe case of norovirus kicked in (48 hours of purge every 15-20 minutes) — can’t even be in the same room with the stuff without flashbacks anymore. Even typing that out made feel rough.

Maybe there’s some way to de-program such strong associations but seems like a way to kick a bad habit..

  • I have the same reaction to strawberry ice cream. Not actual strawberries, those are still good, but the flavor that candy companies think strawberries taste like.

    I got very sick fairly shortly after eating a bunch of strawberry ice cream when I was a kid. 25 years later and I still can't stand the stuff.