FDA approval of the first GLP-1 agonist was in 2005 and many diabetics have been taking these drugs for close to 20 years, so we have a pretty good picture of what long term side effects are: mostly GI symptoms, and you can have problems with muscle loss and bone weakening if you lose a ton of wieght. otherwise they are well tolerated.
Been on one for a few years now, it tempered my persistent auto-immune issues. Short term side effects are barely present for me. This stuff has made it so I don't have to be on steroids and antibiotics every other month. I did not start the medication for weight loss purposes, though have lost 10-15lbs, but I attribute that to being off steroids.
Long term? Who knows for sure. Semaglutide has been approved for 9 years. Liraglutide was 2009 and hasn't shown thyroid issues still. Exenatide has been available since 2005.
GLP-1s aren't new and haven't shown widespread negative issues beyond gastrointestinal upset, and that is typically fixed by... drinking more water. The trials in rats have pointed towards potential thyroid cancer risks but those haven't been seen in people.
There is reason to have some healthy skepticism for pharma. But I am sometimes astounded by how unshakably cynical people can be.
I suppose we all could wind up with cancer in 10 years or something hypothetically, due to some unforeseen mechanism. But here's my story.
I went from 200lb to 140lbs at 5' 9" over 3 years. I feel great. I don't need to eat 1000 calories before bed just to sleep through the night. I focus better at work. Blood pressure is back to normal. HDL is back to normal. I can run without joint pain. I feel good about myself. I feel comfortable going on dates. I'm not a near-obese shut-in loner that can't be in a caloric deficit without wrecking my sleep.
Unless there are literally fatal side effects, these drugs seem pretty miraculous.
FDA approval of the first GLP-1 agonist was in 2005 and many diabetics have been taking these drugs for close to 20 years, so we have a pretty good picture of what long term side effects are: mostly GI symptoms, and you can have problems with muscle loss and bone weakening if you lose a ton of wieght. otherwise they are well tolerated.
Been on one for a few years now, it tempered my persistent auto-immune issues. Short term side effects are barely present for me. This stuff has made it so I don't have to be on steroids and antibiotics every other month. I did not start the medication for weight loss purposes, though have lost 10-15lbs, but I attribute that to being off steroids.
Long term? Who knows for sure. Semaglutide has been approved for 9 years. Liraglutide was 2009 and hasn't shown thyroid issues still. Exenatide has been available since 2005.
GLP-1s aren't new and haven't shown widespread negative issues beyond gastrointestinal upset, and that is typically fixed by... drinking more water. The trials in rats have pointed towards potential thyroid cancer risks but those haven't been seen in people.
There is reason to have some healthy skepticism for pharma. But I am sometimes astounded by how unshakably cynical people can be.
I suppose we all could wind up with cancer in 10 years or something hypothetically, due to some unforeseen mechanism. But here's my story.
I went from 200lb to 140lbs at 5' 9" over 3 years. I feel great. I don't need to eat 1000 calories before bed just to sleep through the night. I focus better at work. Blood pressure is back to normal. HDL is back to normal. I can run without joint pain. I feel good about myself. I feel comfortable going on dates. I'm not a near-obese shut-in loner that can't be in a caloric deficit without wrecking my sleep.
Unless there are literally fatal side effects, these drugs seem pretty miraculous.
>I suppose we all could wind up with cancer in 10 years or something hypothetically
Extremely unlikely, GLP-1 receptor agonists have been on the market for more than 20 years now, exenatide being first used in 2005.
Its been decades since it was invented so perhaps we'll find out soon.
I don't know, let's restrict it's use just to be safe. Unproven, unresearched peptides though, we should have the FDA bless them for sell.
It would be pretty funny if it turns out it doesn't have any side effects and it really is just a silver bullet.
you already feel it. we live in a chaotic world which is a consequence of people, especially those with power, live longer than their predecessors.
I, for one, do not welcome our basically-inmortal AI overlords-to-be.-
a cruel destiny for humanity.
Controlled by increasingly unfeeling, sociopathic masters, who grow more and more in power. And now also do not age or get sick.
The power those at the top hold far exceeds any king or emperor throughout humanities history.
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I wonder if people were waiting for horrible side effects to be found after antibiotics were invented.