Comment by faangguyindia
4 hours ago
>This isn't true. Identical people on identical diets will lose the same weight, GLP1 or not.
No, this isn't true.
Even when two people are identical twins eating the same amount of food and doing the same amount of exercise and activities, weight loss will differ because:
Rate of loss of BodyWeight rate is directly proportional to amount of deficit applied!
Deficit = TDEE (total calorie burn of the day) - Intake
If TDEE is not the same, weight loss will differ, regardless of whether the underlying activity level, genetics, or amount of food or everything else is the same.
For more details u can check my post on this: https://macrocodex.app/knowledge/macrocodex/smart-calorie-bu...
>(That part is true.)
Improved insulin sensitivity is associated with lower excess body fat THE MOST and better skeletal muscle metabolic function. Greater lean mass may contribute.
Therefore, if a person on GLP-1 loses more lean mass than one without, they may not actually have better insulin sensitivity.
The two explicitly identical people have the same TDEE.
No, they don't. It's very difficult to have the SAME TDEE even in identical twins, eating the same food and having same activity level.