Comment by Joker_vD

Okay, so let's not do the human trials. Just be content with the modelling (which is known to be imprecise especially where it matters most), and just approve the drug. What would that even solve? Instead of 6 volunteers getting injured, all the customers/patients who bought and took the drug would get harmed.

There is always human trial — the whole history/timeline of people taking a particular medicine is effectively a decades-long human trial. That's actually the only way we learn about long-term side effects, see paracetamol for instance. All you're proposing is we remove a smaller, controlled pre-trial before releasing the medicine into the wilder population. Sorry, but that won't solve anything except for your feeling of moral indignation.