Comment by vee-kay

AFAIK, you can run Civ1 (and other 16-bit games & applications) on Windows 10/11 in 3 ways:

1. Run CivWin on WineVDM: WineVDM, also known as OTVDM (Old 16-bit Windows Virtual Machine), is a compatibility layer that allows users to run many legacy 16-bit Windows applications on modern 64-bit Windows systems. CivWin is the Windows re-release of Civ1, that's recommended due to its high resolution support (e.g., you can play it in HD with cool mods) and some people like the final multiplayer CivNet release too. Credit: @Blake00 on this thread: https://forums.civfanatics.com/threads/using-winevdm-to-play... https://winevdm.com/does-winevdm-work-on-windows-11/

2. DosBox (get the D-Fend Reloaded frontend/GUI, it contains DosBox): https://dfendreloaded.sourceforge.io/ https://www.dosbox.com/mown/index.php

3. VirtualBox or VMWare (virtual machines solution) to install and run a copy of Windows 95/98.

Note that Microsoft removed support for 16-bit subsystems from 64-bit editions of Windows many years ago, beginning with Windows XP Professional x64 Edition.