Comment by ledoge
4 hours ago
FYI, both VP9 and AV1 support lossless as part of their base profiles, so lossless files using those codecs should be compatible with all implementations (at least in theory). Though those profiles only support 4:2:0, so it depends on your use case if that really counts as lossless.
I struggle to think of a situation where the blur of chroma subsampling is acceptable but very high quality or prores isn't good enough, I need lossless.
4:2:0 is not lossless. 4:4:4 with quantizing down to 8-bit YCbCr isn't lossless either. But 10-bit 4:4:4 is reversible back to 8-bit RGB without loss.