Comment by shellac

I've attempted to get researchers to use lossless H.264 to encode CT scans. They typically use directories full of tiffs. Even with intra-slice compression (i.e. tiff compression) they are pretty huge. But H.264 will let you recover the original images to the individual bit, and save a huge amount of space thanks to inter-slice similarities.

They are still using directories of tiff, though.