Comment by Mikho

For long already I use many personas/users of Chrome simultaneously. It's very useful. Especially when you create a dedicated shortcut to a service/web-site on a desktop or even pin it to the taskbar. So I have direct Gmail icon on my taskbar that launches GMail as a standalone headless window and for a particular Chrome persona. Next is another GMail icon (it's possible to change icons if you need or turn on in W10 taskbar settings illustration of Chrome persona in the bottom right corner) with a different account via different Chrome user. They both work simultaneously. For social accounts I use one persona, for business another, for news and entertainment third. So every session very comfortably is saved and loaded only to a selected persona when I start the session. Since any link in any tab could be opened via a different persona/user it's not a problem to open a link from twitter or facebook in completely different persona where I'm not logged in for socials and basically incognito for the services.