Comment by eropple

I'll cape up a little for Jira. You need to have it built and configured by somebody who actually, really cares about how people already work and has the Jira-specific knowledge to express it--and that can be hard when doing the right thing in Jira is as counter-intuitive as it is--but when done right it's really very powerful and can be made to be effective and user-friendly. (I volunteered to be the Jira admin at my new company because I do care and I do understand it well enough to do that stuff--and because I own enough of the other systems it'll have to hook into eventually, anyway.)

On the other hand, I used to work on EHR software. Eff that.