Comment by joshuamorton

The Gates foundation alone has granted more than $2 Billion on Malaria vaccine, control, and protection research.

Vaccines, in general, make a lot more sense for diseases spread by human to human contact due to herd immunity. Since malaria isn't spread that way, vaccines in general would be much less effective. And the number of people you would need to vaccinate is massive (north of one billion), as well as any new children who are born (infants make up a significant number of Malaria deaths).