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Comment by wyxuan

5 years ago

In vitro things usually work out pretty well, but as soon as you hit human trials it becomes really difficult. Hydroxochloroquine worked well against covid in vitro (had a lower toxicity than remdesivir) but turned out that it could be fatal with certain diabetes drugs and actually increased ventilator time needed.

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wyxuan

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honksillet  5 years ago

Source? HCQ has been used for a long time. It is a medication that is usually ordered for chronic conditions. So people might be expected to be on HCQ for YEARS. (Unlike COVID were they could be on the same doses for just days.) It has a well documented side effect profile and drug interact profile known well before COVID came onto the scene.

  • wyxuan  5 years ago

    Et voila: https://www.biorxiv.org/content/10.1101/2020.03.31.018556v1.... Also here's a source on the ventilator time: https://www.dropbox.com/s/8b2govfsa6n0xbq/NEJM_Clinical%20Ou...

    • JonathonW  5 years ago

      I find it strange that this would be a new discovery, considering that even a casual search shows a decently large body of research specifically into the combinations of chloroquine and hydroxychloroquine with metformin.

    • honksillet  5 years ago

      Interesting but not sure how generalizable a study on genetically modified mice is. I threw HCQ and metformin into the Epocrates drug interaction checker and this is what I got back, "Monitor glucose: combo may incr. risk of hypoglycemia, including life-threatening (additive effects)"

  • smt88  5 years ago

    > It has a well documented side effect profile and drug interact profile known well before COVID came onto the scene.

    You could have said the same about using aspirin to treat the flu, which we now know can be very dangerous[1].

    Drugs also "interact" with diseases, leading to different (side) effects in patients with that disease than without it.

    1. https://www.mayoclinic.org/diseases-conditions/reyes-syndrom...

  • voxl  5 years ago

    Why did you ask for a source while simultaneously making claims without sources? The drug is being falsely pushed by the deranged leader of the United States, I would be much more suspicious of you then of anyone claiming to be wary of it. Especially after Dr. Fauci himself told everyone on national television to not get there hopes up about it.

    • honksillet  5 years ago

      Please leave politics out of this. The OP was making very specific claims and I asked for the sources, which he provided. I thought it was common knowledge that HCQ is most often prescribed for chronic conditions (but I could be wrong about that). It is fair to ask for a source though so here is a source. https://reference.medscape.com/drug/plaquenil-hydroxychloroq... Note that for treatment of, say, Rheumatoid Arthritis the treatment duration is indefinite. The suggested dose for off label use of HCQ with covid is a single dose of 800mg, then 4 to 7 days of 400 mg. (That is from the Epocrates app on my phone so I don't have a link to share.)

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Mountain_Skies  5 years ago

Given the age of hydroxochloroquine, how was it not previously known that it had negative interactions with diabetes drugs?