Comment by coolspot
5 years ago
Thank you for in-depth explanation. Is there a book or some website where all this knowledge of ADHD medication usage nuances is collected in one place? Like a missing ADHD manual?
5 years ago
Thank you for in-depth explanation. Is there a book or some website where all this knowledge of ADHD medication usage nuances is collected in one place? Like a missing ADHD manual?
Ironically, erowid and other "drug" related forums contain the best "practical" knowledge and nuances of actually having to take the medication. They're not scientific or robust, but they are empirical. That's why most pharmacists and prescription-writing physicians will look at you funny (or get combative) if you tell them generic brand X isn't as effective/good as generic brand Z for you.
On paper, each generic must pass some bio-equivalency test with the FDA. Most of the time all that means is "we at generic brand X ran our own experiments and concluded that we show similar blood concentrations of drug A, to Brand-Name Z." And then every professional involved in that supply chain writes it off as "basically the same," excluding all the little implementation/manufacturing details that go into each specific producer, much less factory (quality control is frankly disturbing in many of these plants).
You won't find a lot of practical information written within scientific literature, aside from basic chemistry/biology (the low-level details). Most of the time the researchers running these experiments have done less research and have less hands on experience than the people who have to use this medication on a daily basis. Many times reading the scientific literature is just a rabbit hole that leads to nowhere, except feeling like "you're on to something."
Apologies for the rant.
I remember reading a very big thread about MDMA on Bluelight [1]. They were trying to figure out why the MDMA manufactured today is very different empirically compared to the MDMA manufactured in the 80s. Lots of very interesting chemistry discussion One thing I particularly remember is somebody bringing up the example of their cat. Their cat had some digestive issue and couldn't poop so it was prescribed medicine. One brand of medicine worked wonders for the cat, while a generic brand didn't work at all. Both were supposed to be the same exact molecule!
[1]: https://www.bluelight.org/xf/threads/what-is-wrong-with-the-...
Not that I know of. One of the side effects of amphetamine usage is compulsively researching details about amphetamine, so that’s where my knowledge comes from :)
Certainly need to read some of the research literature and places like /r/DrugNerds (that community is super legit). The public health/doctor-y type websites are the worst for actually getting info since they never go into details and often give bad advice, so I’d stay away from the “traditional” resources if you’re trying to go deep