Comment by philipkglass

Problem: taking massive amounts of loperamide to get an opiate effect is a myth.

A decade or so ago I was reading a drug forum where an addict-chemist reported that acylating loperamide extracted from OTC pills allowed it to pass the blood brain barrier and deliver a true opiate high. His only reported test subject was himself, so I don't know if it was a genuine effect or not. And I haven't kept up with drug forums in recent years to see if this idea/technique spread. If so, it could explain the pill quantity restrictions; pseudoephedrine went through many years of changes in packaging/formulation as manufacturers tried to keep their products OTC while placating governments that didn't want those pills used as illicit drug precursors.