Comment by __blockcipher__

> but I don't think it's anything I'd go for if i were only 10% as intense and came with all the twitchy/tweaker effects. The jaw clenching I got from MDMA was more than enough of that.

While we don't know the exact MoA of the jaw clenching, it's likely a form of excitoxicity, presumably a result of excess glutamate firing. This is why high-bioavailability magnesium, such as a chelated magnesium glycinate, helps a lot with the jaw clenching while rolling.

In other words, it's not the serotonin itself that causes the jaw clenching, AFAIK. The "10% of rolling" was me describing just the serotonin dimension of the mdma vs meth experience, not that it would be 10% of the rolly feeling with 100% of the clenching etc :P

> When I said "never," I meant "never." I didn't experience it the first time I took amphetamine, the second time, or this morning.

Very interesting! I definitely have experienced the euphoric high before, but only when starting prescription amphetamines. Yeah, it may have been that you started with a low enough dose, or just that your neurochemistry is pretty resistant to it.

The reason I mentioned the tolerance thing is because there's a common ADHD myth that if someone has ADHD that amps won't get them a euphoric high, and rather will just "calm them down". But in truth anyone can get the euphoria, and most of the "difference in how ADHD people respond to stims" is just an artifact of them having tolerance. It is of course true that ADHD medication can and often does make ADHD people feel more "calm" due to the greater cognitive control etc, but it's not necessarily true that they/we can't actually get "high" off it.

> Again, thank you for helping me understand a bit of the appeal of smoking meth, without actually smoking meth. :-)

Any time :P I've never smoked it myself but having taken it orally for years, as well as having vaporized DMT many a time, I think I have a pretty good imagination for what it would feel like :P