Comment by Scoundreller
4 years ago
> 5HT2a
You sure you don’t mean 5HT2b?
I mean, anything can be toxic with enough dose, but the b-subtype agonists seem a lot more toxic than the a-subtype agonists.
(Fun fact: 6-APB, a “research chemical” recreational substance became an actual research chemical because of it had better 5HT2b selectivity than what was previously used in lab research)
Was thinking of halogenated NBOMe series - observed in humans to have a pretty narrow therapeutic index re: death, cheapish synth, can be vaporized
But yeah 2b could be worse. Or many other targets as well
Funny thing, optimizing "research chemicals" for (1) uncontrolled synthetic pathway and (2) potency is common to Institutional, Druggie, and Terrorist researchers. None of them want to go through the bureaucracy for controlled substances and potency is good for [better controlled experiments / smaller quantities to transport / more killing power]
researchers will really care about selectivity, but potency can help with the amount of paperwork for sure (and cut synth costs!)