Comment by maccard
4 years ago
> it is very safe if used occasionally in small doses (as described above).
Define occasionally, and small doses. Paracetamol/acetaminophen is widely considered to be dangerous for a few reasons - sustained use of "safe" dosages has been shown to have a huge effect on liver failure [0] - it's regularly found in other painkiller, cold & flu, decongestant, and antihistamines. - It's surprisingly ineffective for a large number of people for lots of different kinds of pain - The dosage that can cause critical liver damage is _dangerously_ close to the therapeutic dose.
[0] https://link.springer.com/article/10.1007/s40264-012-0013-7
Commenter was explicit about dosage and pretty clear about frequency. A single dose of 1,000 milligrams in a 24 hour period is indeed small and universally considered to be safe for people with a normal liver.