Comment by frameset

Yes it does, I use a reverse proxy with ssl and have CW on its own subdomain.

There's a plain text config file on the Kobo's memory and one of the config options is the store URL. CW generates you a new one tied to your local CW account in your instance and you replace the standard URL. You can do multi user stuff that way. You can also define a "shelf" and only books on that shelf will sync if you wish, handy if you have a large collection or a small memory Kobo.

The guide on setting up the Kobo sync feature is here: https://github.com/janeczku/calibre-web/wiki/Kobo-Integratio...