Comment by lucidrains
2 years ago
To add to this, the deep learning field has already moved on towards MSA-less structure prediction. None of this would be possible without building on top of the work open sourced by Deepmind.
https://www.biorxiv.org/content/10.1101/2022.07.21.500999v1 https://www.biorxiv.org/content/10.1101/2022.07.20.500902v1
To be overly dismissive is to lack imagination.
How do we know these "MSA-less" models aren't cheating (i.e. learning all MSAs implicitly from their training data)? If they are, they would similarly fail on any "novel" AA sequence (i.e. one without known/learned MSAs)