Comment by dekhn
2 years ago
I did rotations in multiple types of lab as part of my program and I can't say I ever found that students in regular molecular biology labs had nearly as hard a time as structural biologists; SB is its own class of hell. Given the number of papers published in molecular biology that turn out to be "gel was physically cut and reasssembled to show the results the authors desired" (it's much harder to cheat on a protein structure)...
I think this is highly subjective and that every field has its own special hells. For example, in computational biology it's a lot easier to generate results (when things actually work) but conversely it's a lot harder to convince journals. The burden of proof required to publish is sometimes ridiculously high - I had a paper spend almost 3 years in review.