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Comment by sadhd

2 years ago

The prefrontal cortex mediates executive function and working memory. It sends signals into the center of the brain which in turn reciprocated through dopamine neurons. Methylphenidate blocks the reuptake and breakdown of dopamine by MAO. Amphetamine stimulates the receptors on the other brain cells dendritic surface that dopamine stimulates. The middle of the brain then tells the front which tasks to focus on, what items to keep in working memory, and which emotions and behaviors to suppress. Working memory. Executive function. Emotional regulation. Because of a faulty d2 receptor, adhd brains do not respond to dopamine stimulation like neurotypical ones. They in turn fail to sufficiently signal the front of the brain which controls this higher brain function. It is unfortunate that the disease is called attention deficit hyperactivity disorder because it takes focus away from task salience--keeping on track and holding the steps to accomplish complex behavior i.e. The front of the brain. It also results in time blindness or the inability to evoke future potentials against closer consequences resulting in playing vidya instead of doing homework because the consequences are improperly measured by the front of your brain. Stimulants increase dopamine and acetylcholine. Coaching helps maintain task salience. Cognitive behavioral therapy teaches ways to externalize your executive functions and life skills and requires medical therapy in order to be successful. It is best to regard this as executive function disorder and stay away from attention as attention is often misinterpreted or lacks proper context.

Seems snap-25 also causes issues alongside d2. It helps pop out dopamine bubbles, in layman's terms. Dopamine is made in the nerve cell, then it is released outside the cell by a bubble called a synaptic vessel that basically goes inside out. It crosses the gap between cells and attaches to one of 4 dopamine receptors, the most important of which is d2 for adhd and amphetamine. It is then vacuumed up from that gap between cells by a set of proteins that can be blocked by ritalin, just like zoloft blocks the vacuum for serotonin. It then gets broken down by monoamine oxidase, another potential target for lots of therapies. This stuff is real folks and backed by knockout studies and fMRI scans.