Comment by Kerrick

> Monospaced fonts are generally incompatible with one another. Each one uses different metrics, making it impossible to mix different fonts. Each Monaspace font is designed to be seamlessly mixed and matched. Layer more meaning onto code, with a palette that goes beyond colors and bolder weights. Build interfaces for code that require more structure and hierarchy.

FTA. It means you can do things like have inline comments use Radon, docstrings use Xenon, code use Neon, and string literals use Krypton for more visual difference -- without the line heights and columns getting all weird because of it.