Comment by refurb

> Radiation has benefits that your chemical cytotoxics do not. An individual tumor often comprises of many subclonal cancer cell populations, all of which could have unique resistance mechanisms to allow that subclone to survive and proliferate in the presence of a single cytotoxic payload (say from an antibody-drug conjugate).

Interestingly cancers can develop resistance to radiation induced cell damage as well.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914062/

It's been known for a while since distal metastases would develop when primary tumors were treated with radiation.

What might be interesting is dual treatment - use a cytotoxin-link and radionuclide-linked antibodies together. No idea if it's been tested, but it's an obvious approach since combination therapy is being attempted with damn near every cancer therapy.