Comment by yannyu

The cost driver for fabbing out wafers is the number of layers and the number of usable devices per wafer. Higher layer count increases cost and tends to decrease yield, and more robust designs with higher yields increase usable devices per wafer. If circles or other shapes could help with either of those, they would likely be used. Generally the end goal is to have the most usable devices per wafer, so they'll be packed as tightly as possible on the wafer so as to have the highest potential output.