Comment by Traubenfuchs

2 days ago

We already have one solution to the problem.

Finasteride or dutasteride. They control BPH perfectly, while also treating male pattern baldness. Combine with daily tadalafil to offset any chance of the dubious sexual side effects, while also reducing gynecomastia (it's also an aromatase inhibitor!). Make sure to have regular 5ari-aware PSA screenings to make sure high grade cancers are caught and you are golden.

fin/dut + tad are my favorite medications to keep men fresh for many more years than intended by nature.

Have your children before you start though, as dut will probably make you sterile eventually.

18 comments

Traubenfuchs

Reply
elric  2 days ago

Two lifelong medications + frequent screening does not sound like "a solution" to me.

That being said, the article does state that its proposed treatment doesn't last forever, though I couldn't find any numbers on how long it is expected to last.

formerly_proven  2 days ago

Giving 90% of the gender that looks actually great with hair on their head MPB is easily one of the biggest sleights evolution has committed against our species.

I've personally had very little luck with official channels there. Most won't prescribe anything for hair loss, several dermatologists said to just get used to it, one would prescribe fin pills, i.e. systemic - which did eventually give me pain in the breast tissues (so I ceased using it), but not topical, citing that it's too new on the market. I was unable to find anyone who would or even could look at serum DHT. I eventually settled on just paying one of these apparently legal telemedicine vendors 20 bucks per topical fin prescription.

  • Traubenfuchs  2 days ago

    > which did eventually give me pain in the breast tissues (so I ceased using it)

    You already decided to take one hormonal disruptor, so why not go all the way? Find a private andrologist that prescribes you fin/dut + an aromatase inhibitor. Daily tadalafil also acts as aromatase inhibitor by the way. Should be enough to offset the estrogen increase from finasteride. It's worth a try.

    I personally don't really believe in topical min/fin/dut: You are probably just getting the same effects and side effects you'd get from a lower oral dose.

    The studies on topical finasteride support this. You just believe it's not in your blood and thus there is no nocebo effect to give you ED but it very much is.

teknico  2 days ago

I’ve been prescribed, and taking for a while now, daily Dutasteride plus Silodosin (Urorec). However, the latter has the unpleasant side effect of suppressing ejaculation.

Tadalafil (Cialis) does not seem to do the same, however other potential side effects involving sight and hearing are listed.

I’ll ask my doctor if such a swap would be advisable.

manmal  2 days ago

I‘ve been holding off on fin because of some people developing post-fin syndrome. Is Tad addressing this hazard in your view?

  • Traubenfuchs  2 days ago

    In a framework where one believes PFS to exist (I strongly believe it doesn't), tad would, at best, treat a few of the symptoms of PFS.

    I believe people with self diagnosed PFS have a mix of mental illness and (sometimes) non diagnosed physical illness.

    I'd like to see a self diagnosed PFS sufferer not get an erection, pumped up on 150 mg sildenafil + 10g L-Citrullin.

    > Is Tad addressing this hazard in your view?

    Let me address your question from a different angle: Being on an sufficient amount of daily tadalafil would certainly reduce the chance of you believing you got PFS, because it would guarantee you a working erection in any situation.

    • bladley  2 days ago

      Hi - there is no official diagnosis for "PFS". I have it in the sense that I have penile tissue scarring confirmed by medical imaging, with a urologist's opinion that finasteride was the likely cause. Yes, tadalafil does often help in my case, but the reduction in function is permanent and I doubt I will ever be my pre-finasteride self again.

    • manmal  2 days ago

      Thanks for sharing your view. I think the possibility of something like PFS existing is real, simply because 5ARIs have widespread physical effects - I mean they regrow hair and reduce sperm motility. Why would the brain or nervous system be excluded from being affected? Eg one male hormonal contraceptive pill study was aborted in 2016 because one participant got suicidal.

      1 reply →

ta12653421  2 days ago

daily Taladafil in combination with daily Finasterid?

Good luck :)

I do not know about Finasterid in detail, but the small-printing for Taladafil says clearly its _not_ for daily use.