Comment by derektank

2 days ago

>The sperm competition then discards the random choices that happened to be bad, implementing an optimum search algorithm.

Only a very small percentage of sperm (less than 5%) are chromosomally abnormal. Meanwhile, the vast majority of sperm are morphologically abnormal in some way. So there's not really a tight relationship between genetic problems and sperm fitness. Men with infertility due to low motility, for example, are capable of having perfectly healthy children with those low motility sperm through IVF.

>The DNA of the sperm cells is generated by a random generator, which is the meiosis mechanism, which randomly shuffles then randomly discards half of the father DNA.

Meiosis also occurs in women (technically in the female fetus), but women generally produce only a single egg each ovulation.

>Many embryos will die very soon, without ever developing, rejecting other bad random choices.

A very large number of zygotes/blastocysts survive until implantation, upwards of 50%. And of those that do, maybe 20-40% are miscarried before 12 weeks. All things considered, about 1 in every 4 fertilized eggs results in a successful pregnancy.

So yes, it's absolutely true that the body filters out chromosomally abnormal germ cells and zygotes. But an egg is orders of magnitude more likely to survive than a sperm (even if you take into account the eggs that die in the uterus without being released). And the overwhelming reason is that the egg is simply in a much less hostile immune environment.

> So yes, it's absolutely true that the body filters out chromosomally abnormal germ cells and zygotes.

> A very large number of zygotes/blastocysts survive until implantation, upwards of 50%. And of those that do, maybe 20-40% are miscarried before 12 weeks.

That’s with sperm going to a filter process for genetic abnormalities before fertilization. If hypothetically 5% fewer zygotes survived that would have real consequences not just for humans but in terms of increasing variability in litter sizes for mammals with multiple births etc.