Comment by esseph

8 months ago

I know people personally that psilocybin, LSD, and other substances do nothing for. All of them also have existing mental health disorders (extreme generalized anxiety, depression, bipolar, etc.).

That could be an interaction with the meds they take for those conditions, couldn't it? I seem to recall that SSRIs in particular could mitigate the effects of the hallucinogen.

  • Yes, also that was accounted for with doctors notice and slow tapers off medications over months.

Nothing as in there is no outside noticeable change in behavior and they report no change in speaking, or nothing as it relates to the topic of this thread, in that they have no profound or spiritual experiences?

  • They might get a slight body high even on what would otherwise be considered heroic doses for their weight.

    Things like lemon-tek to make the psilocybin more bioavailable were also not impactful to them, while being apparently extremely impactful for others.

Fwiw I find that, due to my antidepressants, i need 3x the dose to have the equivalent experience as my friends.