Comment by tech_ken

I think it's a mix of set and setting combined with people who have probably never taken any kind of drug aside from alcohol and maybe infrequent cannabis usage. People who take LSD "many times" usually come to it after already being able to handle themselves on some psychedelic substance, so the experience is less all-encompassing and more mundane. Some priest who's never even been contact high, sitting in a room with religious iconography and being prepped to experience something spiritual, seems likely to have a very different experience.