Comment by fnord77
2 days ago
5-Meo is kind of nasty because it has a non-linear pharmacology.
the normal dose is 5-10mg, but LD50 in sheep is about 100mg, it might be as low as 30mg in humans.
It absolutely should not be legal, at least to anyone. Perhaps require training in dealing with drugs with a low therapeutic index
LD50 in sheep:
1–5 mg/kg IV
1–2 mg/kg SC
85 mg/kg O
In mice:
75–115 mg/kg IP
48 mg/kg IV
113 mg/kg SC
278 mg/kg O
They were administering over 30mg to humans in trials. (Metzner (2013); Shulgin and Shulgin (1997); Ott (2001); Davis et al. (2018); Uthaug et al. (2020a))
Sheep are susceptible to toxicity from certain tryptamine alkaloids because of their physiology.
These alkaloids, especially those that are N,N-dimethylated, can trigger neurological symptoms in sheep, such as convulsions, spasticity, and gait issues. The alkaloids are suspected to affect the brain and spinal cord by interacting with serotonin receptors.
5-MeO-DMT is an N,N-dimethylated compound. Its full chemical name is 5-methoxy-N,N-dimethyltryptamine. That indicates the presence of two methyl groups attached to the nitrogen atom of the tryptamine backbone.
Stay safe, everyone!
The Human-Equivalent Dose for IV administration is roughly ~300mg for a 100kg human.
> it might be as low as 30mg in humans.
That seems quite unlikely given that there are many 30mg dose trip reports, going as far back as TiHKAL.
Tell me you never studied basic med chem or pharmacology without telling me...
You can't use animal models for dose, you have to convert to hED (Human-Equivalent Dosage). You can estimate this generally with allometric scaling:
https://drughunter.com/practical-pk-calculators
Also, animal physiology varies.
Beta-adrenergic agonists like clenbuterol make mice wildly muscular, which unfortunately is not the case in humans, for example.